The mailing list for listmasters using Sympa

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Is it practical for another application to control the subscribers who are on 
a
mailing list by solely using email posted commands?  In other words, if I have
a separate application that has special logic for who can join a list, when
they have to leave, etc, could this application use Sympa's email commands as
an API?  (Assuming mailing list sizes of 1,000 to 5,000)